The objective of this study was to assess the impact of closed incision negative pressure therapy (ciNPT) on groin incision complications after infrainguinal bypass and femoral endarterectomy.

Patients (n = 242) undergoing infrainguinal bypass (n = 114) or femoral endarterectomy (n = 118) at five academic medical centers in New England from April 2015 to August 2019 were randomized to ciNPT (PREVENA [KCI, San Antonio, Tex]; n = 118) or standard gauze (n = 124). The primary outcome measure was a composite of 30-day groin wound complications (surgical site infection [SSI], major noninfectious complications, or graft infection). Secondary outcome measures included 30-day SSI, 30-day noninfectious wound complications, readmission for wound complications, significant adverse events, and health-related quality of life by EuroQol-5 Dimension 3-Level survey.

The ciNPT and control groups had similar demographics, comorbidities, and operative characteristics. There was no difference in the 30-day primary composite outcome (ciNPT vs control, 31% vs 28%; P = .55). SSI at 30 days was similar (ciNPT vs control, 11% vs 12%; P = .58).

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