Results from a small study published in Neurology indicate that migraine with aura appears to be associated with neuroimmune activation/neuroinflammation, supporting a possible link between cortical spreading depression (CSD) and glial activation that has been observed previously in animals. The comparison of migraineurs with healthy controls found that the former demonstrated standardized uptake value ratio elevations in nociceptive processing areas—such as the thalamus and primary/secondary somatosensory and insular cortices—and the visual cortex, which has previously been shown to be involved in CSD generation.

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