Neutrophilic dermatoses (ND) are a set of skin disorders distinguished by an aseptic buildup of polymorphonuclear leukocytes. The presence of ND in the presence of myeloid malignancies, most notably myelodysplastic syndrome, and myelogenous acute leukemia, is not uncommon and is frequently linked with a poor prognosis.
Recent research has advanced our knowledge of the pathogenesis of myeloid malignancy-associated ND. Researchers examine the clinical range of myeloid malignancy-associated ND, with a focus on newly discovered pathways.
In the skin, myeloid leukemia cells retain the ability to differentiate into polymorphonuclear leukocytes. Several investigations have found a clonal relationship between myeloid malignancies and ND. Activation of autoinflammatory pathways in myeloid clonal cells may potentially be implicated in this situation.
Reference:link.springer.com/article/10.1007/s40257-018-00418-2
