No significant association was observed between insulin use and allcause dementia among individuals with T2D previously exposed to two noninsulin antihyperglycemic medications, according to a study published in Diabetes Care. John- Michael Gamble, BSc, MSc, PhD, and colleagues reexamined this correlation in 7,863 insulin and 25,230 noninsulin–users. New insulin–users and new noninsulin–users were from a restricted cohort of patients who previously received two noninsulin antihyperglycemic classes, to adjust for confounding by diabetes severity through design. Researchers further adjusted for confounding using conventional multivariable adjustment and inverse probability of treatment weighting based on the high-dimensional propensity score algorithm. Cause-specific hazards models with death as a competing risk was used to estimate the HR (95% CI) of dementia. Over a median follow-up of 3.9 (5.9) years among insulin users, 78 dementia events occurred; over 4.6 (4.4) years among noninsulin– users, 179 events occurred. The HRs (95% CI) of dementia for insulin use versus noninsulin use was 1.68 (1.29-2.20) before adjustment and 1.39 (1.05-1.86) after multivariable adjustment
