In immunocompromised hosts, norovirus infection is a new chronic infection. The purpose of this study is to address the pathophysiology of Norovirus infection and to investigate mechanistic models for chronic infection/shedder condition, particularly in individuals with immunological deficiencies. Chronic Norovirus infection is being more linked to enteropathy in patients with both main and secondary immunological deficiencies. In the immune deficiency community, there is continuing discussion about whether it is a true causal agent of enteropathy or only a bystander. The study discusses the history of Norovirus infection, its immunology and viral structure, as well as the foundation for preventative and vaccine methods. In this study, researchers also propose a disease model in immune deficient patients that creates an environment for illness to become chronic, as well as novel horizons for disease modification and prevention.

Norovirus is the most prevalent cause of acute gastroenteritis in the general population, but the variables that contribute to its persistence in individuals with immune deficiencies require more comprehensive research. This should involve an evaluation of the host, microbiome profiles, and viral pathogenic factors.