Many research on oral immunotherapy (OIT) has been done in recent years, but few have focused on severe food allergies. The goal of this study was to evaluate the effectiveness and safety of oral immunotherapies for individuals with severe food allergies. Researchers examined several immunotherapy papers published over the last few years, as well as reports concentrating on severe food allergies. In addition, they looked into current studies on OIT and novel food allergy management.

Immunotherapies that target low-dose antigen exposure and oral food challenges that use low-dose target volumes may be safer than traditional OIT. It is important to examine which immunotherapy regimen is most suited based on the severity of the allergy.