The study was done to evaluate perinatal and obstetric outcomes for mother and fetus and risk of GTN.

Four or more cases confirmed by histopathology and providing data on pregnancy outcomes and GTN were observed to gather data.

Two reviewers independently reviewed abstracts and full‐text articles. The quality of the studies was assessed and a meta‐analysis was performed.

14 studies met the eligibility criteria to be included in the study. The incidence of maternal complication in ongoing pregnancies was 80.8% and included vaginal bleeding, hyperthyroidism, and pre‐eclampsia. There were overall 50% live births in ongoing pregnancies and 34% of the total cases were subsequently diagnosed with GTN. Substantial and significant heterogeneity was found for the incidence of preeclampsia indicating variability in reporting the incidence of some obstetric complications between studies.

Understudy patients have a high risk of perinatal complications, low live‐birth rates, and around a third of them will develop a GTN and should be managed by specialized multidisciplinary teams.

The study concluded that there is a high rate of obstetric and oncologic complications in patients presenting with a complete hydatidiform mole and coexistent normal fetus.

Reference: https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.16283