One of the most typical symptoms in individuals with primary antibody deficiency (PAD) is pulmonary problems, which dramatically increase morbidity and death. For a study, researchers sought to concentrate on recent research on bronchiectasis and obstructive pulmonary illness in PAD. They also tried to consolidate information from the immunocompetent population because there were little specific data on individuals with PAD, and care generally followed basic guidelines.

Reduced immunoglobulins and decreased CD4 cells were two potential risk factors for the onset and progression of bronchiectasis. Additionally, the development of the illness and local inflammation may be influenced by Pseudomonas aeruginosa and a modified microbiome. Confirmation in PAD was necessary for findings about the role of neutrophils and eosinophils in the afflicted immunocompetent group. There was a severe lack of information on chronic obstructive pulmonary disease in PAD despite the illness’s significant worldwide prevalence. Lower IgA and IgM levels are linked to asthma in PAD. However, it needed to be clarified why different PAD groups had different prevalence rates. Recent findings of non-IgE-mediated asthma pathomechanisms might be very interesting to PAD patients.

An interdisciplinary team approach combining immunology, pulmonology, infectious disease, and physiotherapy was necessary to manage PAD patients with chronic lung illness. To ensure a more precise view of prevalence and illness courses, diagnostic techniques should be unified.

Reference: journals.lww.com/co-allergy/Abstract/2022/12000/Bronchiectasis_and_obstructive_lung_diseases_in.2.aspx