The study was done to investigate the association between OCT and brain volume and SCA parameters in patients with relapsing MS and to assess their independent associations with disability.

This was a cross‐sectional analysis of 90 patients with MS who underwent OCT and MRI examination. Values of pRNFL, GCIPL, and the inner nuclear layer of eyes without previous optic neuritis were obtained. SCA and BPF, grey, and white matter fractions were obtained. Multivariable regression analyses were conducted with a disability as a dependent variable.

Lower pRNFL thickness and lower GCIPL volume as well as lower BPF, grey matter fraction, and SCA were associated with longer disease duration and a higher Expanded Disability Status Scale score. Lower pRNFL thickness and GCIPL volumes were associated with lower BPF and SCA. In the multivariable logistic regression analyses, pRNFL thickness and GCIPL volume outperformed MRI in predicting disability.

The study concluded through its findings that OCT measures correlate with the brain and spinal cord atrophy and appear more closely associated with a disability than MRI volumetric measures.