All patients undergoing organ transplantation must adhere to a complicated treatment regimen for the remainder of their lives. For a study, researchers sought to evaluate the pragmatic strategies utilized by various studies to improve self-management behavior adherence. A systematic study was undertaken using keywords in 5 databases between 2010 and August 2021. All eligible research was published in English and established self-management strategies to improve patient care in solid organ transplantation. The interventions were subjected to thematic analysis to identify the primary descriptive categories. The research critical appraisal program (CASP) was utilized to evaluate the quality of the included papers. Of 40 of the 691 articles retrieved matched the inclusion criteria. About 32 of these studies focused on the post-transplantation period. The thematic analysis identified 5 primary areas: e-health programs for telemonitoring, non-electronic educational programs, non-electronic home-based symptom-monitoring programs, electronic instructional plans for self-monitoring, and telerehabilitation. Most studies (72.5%) concluded that developed programs and deployed solutions had statistically significant beneficial effects on transplant patient self-management behavior improvement. The results demonstrated that patient care’s psychological, social, and clinical elements might be addressed through patient collaboration to improve organ transplantation. By placing the patient at the center of care, such programs could be implemented during candidate selection, on the waiting list, and after transplantation.