The study aimed to assess whether the ovarian reserve markers AMH and antral follicle count (AFC) was lower among women using the POP or LNG-IUS and similar to the decrease observed in COC pill users.

This retrospective study comprised 565 hormonal contraceptive users and 983 non-hormonal contraceptive users, who Researchers saw in two Danish fertility assessment and counseling clinics. Adjusted multiple regression analysis was used to examine AMH and AFC’s differences between hormonal and non-hormonal contraceptive users.

Compared with non-hormonal contraceptive users, AMH was 31.1% lower among COC users, 35.6% lower among POP users, and Researchers saw 17.1% lower among LNG-IUS users; no significant differences among vaginal ring users. Compared with non-hormonal contraceptive users, AFC was 31.3% lower among COC users and 29.7% lower among POP users; Researchers saw no significant differences among LNG-IUS or vaginal ring users. Ovarian volume was more than 50% reduced among COC and vaginal ring users but was unchanged among POP and LNG-IUS users.

Assessment of ovarian reserve markers among users of all hormonal contraception types should be interpreted cautiously and the type of contraceptive method considered.

Reference: https://www.tandfonline.com/doi/full/10.1080/13625187.2019.1702158