PD-1 Blockade in Classic Hodgkin Lymphoma has proven to be a very effective way to treat the condition. Blockade of signaling via programmed death-1 is very useful and is an effective strategy in the therapeutic pathway. PD-1 blockade has made a major impact on the management of patients with relapsed cHL and is now the standard of care in this patient population. We have discussed the efficacy of the immune checkpoint inhibitors nivolumab and pembrolizumab in patients with relapsed or refractory cHL who are ineligible for treatment with an autologous stem-cell transplant.
In a study of 96 patients (ORIENT-1), treatment with sintilimab resulted in an overall response rate of 80.4%, including a complete response rate of 34%. The progression-free survival was 77.6% at 6 months.A second anti-PD-1 antibody, tislelizumab, was tested in a clinical trial of 70 patients and resulted in an objective response in 87.1% of patients treated, 62.9% of whom achieved a complete response.progression-free survival rate was 74.5% after 9 months. In the next phase a third anti-PD-1 antibody, camrelizumab, 57 of 75 (76%) patients had an objective response, including 28% who had a complete remission.
From all the above we surely can come o a point of conclusion that Antibodies that block PD-1 signaling are very much efficient and helpful for the patients with cHL.
https://ascopubs.org/doi/full/10.1200/OP.20.01020
