Many patients with a perinephric abscess (PA) will benefit from drainage. However, some patients may not benefit from percutaneous drainage, and surgical drainage might cause trauma and slow recovery. Researchers present the case series of 11 patients with PA who were successfully managed with percutaneous nephroscopy and ultrasound-guided negative-pressure suction in the setting of a local anesthetic. From January 2013 to June 2020, 11 individuals who had PA surgery were included in this case study. Each patient had percutaneous nephroscopy with ultrasound-guided negative-pressure suction. It recorded how long the surgery took, how much blood was lost, how much pus was suctioned, how long it took for the patient’s temperature to return to normal, how long they were in the hospital if any difficulties occurred during the procedure, and so on. On average, each patient was 59 years old (53–69). Hypertension affected 8 patients, type 2 diabetes affected 6, rheumatoid arthritis affected 2, and renal calculi affected 2. About 11 patients had procedures, and all went well. The abscess was drained in 8 patients with 1 channel, in 2 patients with 2 channels, and in 1 patient with 3 channels. Blood loss during surgery averaged 16 (10-20) ml, and the procedure took an average of 44 minutes (30-65). Intraoperative pus suction volume was 280 (200-400) ml, postoperative drainage tube indwelling period was 8.2 (3-6) days, and the time to return to normal body temperature was 0.8 (0.5-2) days. The median length of time spent in the hospital following surgery was 9 days. There were no major issues during or after surgery. An average of 4.8 (3-8) months were spent in follow-up after surgery, during which no recurrences occurred.