Shoulder discomfort is frequently caused by rotator cuff tendinopathy. The purpose of this study was to compare periarticular dextrose prolotherapy to physiotherapy for the treatment of chronic rotator cuff tendinopathy in the short term. At a university hospital, we conducted a randomised clinical study with two arms. A total of 66 individuals with chronic rotator cuff tendinopathy, as determined by magnetic resonance imaging, were randomly assigned to one of two groups. Changes in shoulder pain intensity and disability index were measured using a questionnaire for Shoulder Pain and Disability Index. Participants followed a 3-week fitness regimen consisting of 10 30-minute sessions. They utilised 8 mL of 12.5 per cent dextrose and 40 milligrammes of 2% lidocaine for prolotherapy. The combination was injected superficially around the shoulder joint and to sensitive sites along the suprascapular nerve twice at 1-week intervals. Neurofascial dextrose was more successful than PT in relieving pain in two weeks, and the results were comparable three months later. Dextrose was more helpful than physiotherapy for impairment 2 weeks and 3 months after the treatments. The alterations in the physiotherapy group, on the other hand, appeared to be more long-lasting. 

Both treatments are helpful for treating rotator cuff tendinopathy in the short term. However, as a first treatment, prolotherapy is more effective. Furthermore, as compared to physiotherapy, dextrose prolotherapy has a considerably shorter treatment period.