This study states that Critical limb-threatening ischemia (CLTI) of the lower extremity is associated with high rates of morbidity, including amputation and death. Unfortunately, there is a paucity of data related to how periprocedural metrics affect the success of these interventions for CLTI. Perioperative anemia has been shown to affect outcomes in patients suffering from myocardial ischemia. It can be postulated that the same physiologic principles can be applied to CLTI. We hypothesize that perioperative anemia may contribute to a higher risk for amputation in patients receiving interventions for CLTI. We performed a single-center, retrospective cohort study of patients undergoing procedures for CLTI at The Ohio State University Wexner Medical Center. Patients aged 18 to 100 years with International Classification of Diseases, Ninth Revision or Tenth Revision coding for CLTI of the lower extremities were included. Patients with interventions for claudication or acute limb ischemia were excluded. Demographic data and hemoglobin levels before intervention were obtained. The primary outcome was amputation of the affected limb after intervention. Secondary outcomes included the need for reintervention, 30-day mortality, and 30-day major complication rate. Statistical analyses using univariate and multivariate analysis with logistic regression models were performed to compare amputation rates with these variables.

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