The goal of this study is to define anaphylactic endotypes by describing distinct clinical presentations of anaphylaxis (phenotypes) in connection to the underlying processes and possible biomarkers. This may help to improve knowledge, management, and consequences of such severe responses. Anaphylaxis phenotypes have been defined, ranging from the typical type I to those resembling cytokine storms or complement-mediated responses. The underlying processes differ, and biomarkers of the cells and systems involved are being discovered (tryptase, IL-6, bradykinin etc.)
Identifying particular phenotypes/endotypes will allow precision medicine to be used in patients with anaphylaxis, offering insights into the best treatment in each situation.
