For a study, researchers sought to understand that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is portrayed by the enactment of a cytokine storm got to an overabundance arrival of cytokine (interleukin [IL]-6, interferon [IFN] I, C-X-C theme chemokine ligand [CXCL]10, growth rot factor [TNF]-α, macrophage inflammatory protein [MIP]1) because of an uncontrolled resistant actuation. There has been a fivefold expansion in the number of instances of pityriasis rosea during the SARS-CoV-2 pandemic. Utilizing the watchwords “pityriasis” and “COVID-19,” they completed a PubMed search, remembering all articles for the English language distributed until November 2021. Investigators intended to explore the possible association between SARS-CoV-2 and pityriasis rosea (PR). Pityriasis could be viewed as an immunological sickness because of the contribution of cytokines and chemokines. The examination yielded 65 articles, of which 53 were not thought of; the others (n=12) concerning the relationship between PR and COVID-19 were remembered for the review. They propose 2 components basic to the contribution of the skin to viral contaminations: infections straightforwardly influencing the skin or potentially prompting host resistant reaction in this way causing cutaneous signs; and infections as a potential inducer of the reactivation of another infection. The main component was likely connected with the arrival of promising inflammatory cytokine and contamination-related biomarkers; in the second, a few pathways could be engaged with the reactivation of other dormant infections (human herpesviruses 6 and 7), for example, a cytokine-cytokine receptor collaboration, the Janus kinase signal transducer and activator of record flagging pathway, and the IL-17 flagging pathway. They, in this manner, accepted that a cytokine storm could be straightforwardly or by implication liable for a cutaneous sign. More examinations were expected to find clear pathways included and accordingly affirm the theories.