Polymorphism –509C/T in the promoter of the TGFB1 gene is implicated in the pathogenesis of asthma. This polymorphism might also act to regulate the development of AR. This study was done to investigate whether –509C/T is associated with AR susceptibility and severity in a Han Chinese population.

263 patients with persistent AR and 249 healthy controls were enrolled in the study. AR patients were classified as mild or moderate/severe AR groups according to the Allergic Rhinitis and its Impact on Asthma classification.

Difference was found in the allele frequency of TGFB1 –509C/T between AR patients and healthy controls but not in the genotype frequency. TGFB1 –509C/T showed difference between the mild AR group, the moderate/severe AR group, and the control group; between the moderate/severe AR group and the control group; between the mild AR group and the moderate/severe AR group; but not between the mild AR group and the control group.

This study concluded through its findings that the TGFB1 promoter polymorphism –509C/T may be associated with the susceptibility and the severity of persistent AR of Han Chinese, but the functional relationship still needs clarification.

Reference: https://journals.sagepub.com/doi/full/10.1177/1945892420913441