This study states that Parkinson’s disease (PD) states that patients have reflected a high prevalence of polyneuropathy (PNP) alpha‐Synuclein pathology in dermal nerve fibers already at early disease stages. 

The main objective of this study was to analyze associations between the prevalence and severity of PNP symptoms in PD patients which are motor and non motor. The study shows the high weight of fringe peripheral nervous system disease in Parkinson’s disease. It advocates further investigations to outline the hidden pathophysiological components to streamline treatment approaches for PD, including the related PNP. Parkinson’s disease (PD) is the most widely recognized persistent neurodegenerative development issue and presents with both engine and nonmotor symptoms. Nonmotor highlights incorporate rest modifications, dementia, sorrow, clogging, and torment that may seriously bargain personal satisfaction and may on the other hand impact the weight of engine manifestations including gait. Polyneuropathy (PNP) is a regular yet frequently disparaged confusion of PD. There are a lot of changing assessments about the general pervasiveness of PNP in PD which is somewhere in the range of 19% and 55% while simply 8% to 9% of age‐related peers are affected.3, 4 The qualities of PD‐associated PNP are just inadequately contemplated.

Reference link- https://onlinelibrary.wiley.com/doi/10.1002/acn3.51182