PPIs are drugs capable of blocking the gastric pump H, K-ATPase in order to inhibit gastric acid secretion. Omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole belong to the PPIs category. Although PPIs have a good safety profile, allergic reactions to these molecules can occur. The real rate of hypersensitive reactions to PPIs is unknown. The aim of this retrospective study is to evaluate the rate of hypersensitive reactions to PPIs in patients admitted to our unit with a history of drug hypersensitivity.

The data of 1229 patients with adverse drug reactions were obtained from the database, researchers extrapolated the data about PPI reactions. 12 patients had a history of hypersensitive reactions to PPI. Pantoprazole was the most frequently PPI involved. Based on patient personal history in some cases, an oral challenge test was performed for an alternative anti-acid drug and none of them had adverse reactions.

According to the current findings and literature, ADR caused by PPIs is ever-increasing. Adverse reactions to these drugs are still under-reported; however, considering the frequency of their prescription worldwide, the risk of severe allergic events is low. This should be useful to help physicians in choosing the molecule to prescribe.

Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-019-0104-4