In patients with atrial fibrillation (AF), prediabetes was linked with an increased risk for heart failure (HF), according to a study published in Diabetes Care. Kai-Hang Yiu, MD, MBBS, and colleagues investigated patients newly diagnosed with AF (N=17,943) who were divided into three groups: T2D, prediabetes, and normoglycemia. Death was defined as the competing event via the Fine and Gray competing risks model. HF developed in 15.7% of patients with prediabetes, 17.7% with diabetes, and 14.0% with normoglycemia during a median follow-up of 4.7 years. Prediabetes was linked with a greater risk for HF compared with normoglycemia (sub-distribution HR [SHR], 1.12; 95% CI, 1.03-1.22). In patients with prediabetes at baseline, 11.1% progressed to diabetes and 8.6% reversed to normoglycemia at 2 years. Progression to diabetes was linked with an elevated risk for HF (SHR, 1.50; 95% CI, 1.13-1.97), whereas reversion to normoglycemia correlated with a decreased risk (SHR, 0.61; 95% CI, 0.42-0.94) compared with remaining patients with prediabetes.
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