BAO leads to high rates of morbidity and mortality, despite successful recanalization. The discordance between flow restoration and long‐term functional status clouds clinical decision‐making regarding further aggressive care. The study was done to develop and validate a practical, prognostic tool for the prediction of a 3‐month favorable outcome after acute reperfusion therapy for BAO.
In the derivation cohort of 59 patients, independent predictors of the favorable outcome included smaller brainstem infarct volume on post‐procedure magnetic resonance imaging and younger age. POST‐VB score was calculated as age + (10 × brainstem infarct volume). POST‐VB score demonstrated excellent discriminatory ability and adequate calibration in the derivation cohort (Center A). It performed equally well across the three external validation cohorts. Overall, a POST‐VB score < 49 was associated with an 88% likelihood of a favorable outcome, as compared to 4% with a score ≥ 125.
The outcomes of the study concluded that the POST‐VB score effectively predicts a 3‐month functional outcome following acute reperfusion therapy for BAO and may aid in guiding post‐procedural care. Through this study, the researchers developed and validated a practical, prognostic tool for the prediction of a 3‐month favorable outcome after acute reperfusion therapy for BAO