Sarcoidosis lung transplant referral criteria are less well-established than those for other chronic lung illnesses. Waitlist mortality may provide hints for locating clinical elements that call for early referral. To enhance the referral standards for sarcoidosis patients, researchers sought to discover factors for transplant queue mortality for a study.

They performed a retrospective study on 1,034 sarcoidosis patients listed for lung transplantation in the Scientific Registry of Transplant Recipients (SRTR) database between May 2005 and May 2019. After the Lung Allocation Score (LAS) was established, all patients were listed. They contrasted patients who passed away while waiting for a transplant with those who received it. Univariate and multivariate analyses using logistic regression modeling were used to evaluate potential determinants of waitlist mortality.

After LAS was implemented, 1,034 candidates were listed; 704 underwent transplants, and 110 passed away while waiting. Female gender (OR 2.445; 95% CI 1.513-3.951; P = 0.0003) and severe pulmonary hypertension (OR 1.619; 95% CI 1.067-2.457; P = 0.0236) were significant predictors of waitlist mortality, according to multivariate analysis. Taller minimum donors (OR 0.606; 95% CI 0.379-0.969; P = 0.0365) and blood type B (OR 0.524; 95% CI 0.281-0.975; P = 0.0415) were linked to a lower risk of passing away while waiting for a transplant.

Taller minimum donor height and blood type B were discovered to be protective variables against mortality on the waitlist among patients with sarcoidosis who were waiting for lung transplants. Early referral for transplantation in patients with these characteristics should be considered because female gender and severe pulmonary hypertension are associated with an increased risk of death.

Reference: resmedjournal.com/article/S0954-6111(22)00273-6/fulltext