Accordingly, researchers aimed to determine the prevalence and genotype distribution of HPV among women with cervical lesions in Shenzhen to evaluate the potential benefit of HPV vaccination programs and inform cervical cancer control policies. Researchers enrolled 5,255 patients admitted to the University of Chinese Academy of Sciences Shenzhen Hospital.

The HPV prevalence and genotype distribution were analyzed using the 21 HPV GenoArray diagnostic assay. 937 out of 5,255 patients showed HPV positivity, of whom 85.81% had a high-risk HPV infection. HPV52 was the most prevalent genotype, followed by HPV58 and HPV16. The HPV prevalence rates among women with a normal cervix, low-grade intraepithelial lesions, high-grade intraepithelial lesions, invasive cervical cancer, and other characteristics were 15.63%, 58.65%, 80.00%, 88.57%, and 15.84%, respectively. HPV16, HPV18, and HPV52 accounted for most cervical lesions, and the infection rates of HPV16 and HPV18 gradually increased with intraepithelial lesion progression.

The study concluded that HPV16, HPV52, and HPV18 played essential roles in cervical lesions’ occurrence and development. This finding has the potential to guide the formulation of HPV screening and vaccination programs and preventive strategies for HPV-attributable cancer in this region.