Infection with the human papillomavirus (HPV) is required for the development of cervical cancer. Although the HPV vaccination is now available, there is still a paucity of large-scale studies on the distribution and risk factors of HPV. The purpose of this study is to look into the genotype distribution and risk factors for HPV infection in Yangqu, China. This study included 10086 women from Yangqu County, all of whom were above the age of 65. Standard HPV DNA testing was used to identify HPV genotypes. The prevalence of high-risk HPV types was 8.80 percent, whereas low-risk HPV types were 0.38 percent. HPV-16, HPV-52, and HPV-58 were the most frequent HPV genotypes. In HPV-positive patients, HPV-18 was only the 11th most prevalent variety. Women aged 50 had the greatest prevalence rate of HPV, whereas women aged 30 had the lowest prevalence rate. The distribution of HPV genotypes differed between the three age groups: 30–49, 30–50, and 50 years. Poor educational level, low income, smoking, age at first sexual experience 23 years old, and number of births 3 times were risk variables that related to the rate of HPV infection.

This big routine clinical practise report of HPV prevalence and genotype distribution highlighted the peculiarities of HPV infection-type distributions in Shanxi Province, which should be addressed when developing comprehensive cervical cancer prevention measures in China, including vaccination.