On chest computed tomography, a 71-year-old man with human immunodeficiency virus negative presented with a stridorous cough and was discovered to have a localised tracheal stenosis accompanied with regional lymphadenopathy. Direct inspection revealed tracheal lesions that were biopsied with a 2.4 mm cryoprobe, confirming the diagnosis of primary tracheal lymphoma. Following treatment, the patient’s tracheal stenosis improved clinically and on imaging. 

This case demonstrates a relatively unusual aetiology of tracheal lesions, as well as the use of cryoprobe over forceps biopsy as a technique to promote optimum tissue capture and diagnosis.