The present study investigated the difference between coagulation and fibrinolysis cascade components between an AR mouse model and control mice.
BALB/c mice were sensitized and challenged with ovalbumin. Multiple coagulation cascade parameters and fibrinolysis systems such as factors II, V, VII, X, and XIII; tissue-type plasminogen activator; u-PA; plasminogen activator inhibitor-1; and fibrin were compared between the AR model group and the control group.
The symptom scores and eosinophil counts were higher in the AR group than in the control group. The mRNA expression level of u-PA was significantly lower, and the expression levels of factor II and factor X were substantially higher in the AR group. Immunohistochemical staining revealed that most of the fibrinolysis and coagulation cascade components were localized to the nasal mucosa’s glands. u-PA was down-regulated in the AR group, whereas fibrin deposition was more prominent in the AR group than in the control group.
The study concluded that in AR, the cascade’s particular components were increased, and the fibrinolysis system was decreased compared to the standard control. This difference may be associated with the fibrin deposition in the mucosa of the AR mouse model.
Reference: https://journals.sagepub.com/doi/full/10.1177/1945892418816015
