Probiotic supplementation in childhood may be useful in avoiding atopic dermatitis (AD); nevertheless, effectiveness findings have been mixed. The purpose of this study was to look into the influence of probiotic supplementation on the risk of Alzheimer’s disease.

Researchers thoroughly searched the PubMed, EBSCO, Embase, and Web of Science databases for relevant papers on probiotic supplementation and Alzheimer’s disease up to March 8, 2018. Infants and children who had probiotic exposure in utero and/or after birth who had not previously been diagnosed with AD were included in the study. To measure methodologic quality, they generated odds ratios (ORs) and 95 percent confidence intervals (CIs) and used the Jadad and Newcastle–Ottawa ratings.


The inclusion criteria were satisfied by a total of 28 studies. Compared with controls, probiotic treatment was associated with less risk of AD (OR 0.69; 95% CI 0.58–0.82, P < 0.0001). The use of probiotics during both postnatal and prenatal periods reduced the incidence of AD (OR 0.67; 95% CI 0.54–0.82). However, investigations of probiotics administered solely during the prenatal or postnatal phase failed to attain statistical significance. Probiotic supplementation throughout both the prenatal and postnatal periods, according to the meta-analysis, lowered the prevalence of AD in newborns and children.