The objective of this study is to deliberately looked through PubMed, Web of Science, Embase, and Cochrane Library until March 2020. Partner considers were incorporated on the off chance that they thought about the prostate disease hazard between individuals with HIV/AIDS and uninfected controls or everybody. The synopsis normalized frequency proportion (SIR) and 95% certainty stretch (CI) were determined utilizing an arbitrary impacts model.A complete of 27 examinations were incorporated for investigation, with in excess of 2780 guys with HIV/AIDS creating prostate malignant growth. The outcomes demonstrated that HIV disease was related with a diminished danger of prostate malignant growth occurrence (SIR, 0.76; 95% CI, 0.64–0.91; P = 0.003), with critical heterogeneity (P < 0.001; I2 = 91.6%). A scope of affectability examines didn’t altogether change the outcomes. Our investigation shows that individuals with HIV/AIDS have a lower rate of prostate malignant growth contrasted and everyone. Be that as it may, huge heterogeneity exists among the included investigations. Further forthcoming investigations with better plans are expected to clarify the relationship between HIV disease and prostate malignant growth. Therefore the wrap up is that Risk of prostate cancer in men with HIV/AIDS is high.

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