For a study, the researchers built on prior research by seeking to quantify spatial and temporal representation resolution in children with 22q11 deletion syndrome (22q11DS), sex chromosome aneuploidy (SCA), and a typically developing (TD) control group. Children with 22q11DS were discovered with the requirement of a more significant magnitude difference between spatial stimuli for accurate identification compared with both the SCA and TD groups (% difference from standard: 22q11DS=14; SCA=8; TD:7; F=8.42, P<0.001). The temporal detection threshold was also higher for the 22q11DS group to both visual (% difference from standard: 22q11DS=14; SCA=8; TD=7; F=8.33, P<0.001) and auditory (% difference from the norm: 22q11DS=23; SCA=12; TD:8; F=8.99, P<0.001) stimuli compared with both the SCA and TD groups, while the SCA and TD groups displayed equivalent performance on these measures (P‘s > 0.05). The Pitch detection threshold did not differ among the groups (P‘s>0.05). The observation of higher detection thresholds to spatial and temporal stimuli indicated further evidence for reduced resolution in both spatial and temporal magnitude representation in 22q11DS, which did not extend to frequency magnitude representation (pitch detection), which was not explained by generalized cognitive impairment alone. The outlines generated further support for the hypothesis that spatiotemporal hyper granularity of mental pictures contributes to the non-verbal cognitive impairment seen in 22q11DS.
Link:jneurodevdisorders.biomedcentral.com/articles/10.1186/s11689-019-9301-1
