The goal of this study was to assess the relationship between race-ethnicity, and neighborhood socioeconomic level, and adherence to National Comprehensive Cancer Network endometrial carcinoma recommendations. The data come from the SEER (Surveillance, Epidemiology, and End Results) cancer registry, which tracked women diagnosed with endometrial carcinoma from 2006 to 2015. After inclusion and exclusion criteria were applied, the sample contained 83,883 women. To assess the relationship between race–ethnicity and neighborhood socioeconomic level and adherence to treatment guidelines, descriptive statistics, bivariate analysis, univariate and multivariate logistic regression models were used. After adjusting for demographic and clinical variables, Black, Latina, and American Indian or Alaska Native women had lower odds of obtaining adherent therapy compared to White women, whereas Asian and Native Hawaiian or Pacific Islander women had greater odds of receiving adherent treatment. After controlling for covariates, there was a neighborhood socioeconomic status gradient: women in the high–middle, middle, low–middle, and lowest neighborhood socioeconomic status groups had lower odds of receiving adherent treatment than those in the highest socioeconomic status group.

This study’s findings indicate that there are racial–ethnic and neighborhood socioeconomic inequalities in National Comprehensive Cancer Network treatment adherence for endometrial cancer. Treatment protocols should not change based on sociodemographics. Interventions are required to guarantee that equitable cancer treatment methods are available to all people, regardless of race, ethnicity, or socioeconomic status.