For a study, researchers sought to analyze segmental and local radiographic boundaries between anterior interbody fusion (ALIF) and posterior interbody fusion (TLIF) to treat L5-S1 isthmic spondylolisthesis to evaluate for changes in these boundaries over the long run. Optionally, investigators considered clinical results using patient-reported outcome measures (PROMs) among methods and inside bunches. Isthmic spondylolistheses were often treated with interbody combinations through ALIF or TLIF approaches. Powerful correlations between radiographic and clinical results were inadequate. Study group checked on pre-and postoperative radiographs as well as Patient-Reported Outcomes Measurement Information System (PROMIS) components for patients who got L5-S1 interbody combinations for isthmic spondylolisthesis in the Mass General Brigham (MGB) wellbeing framework (2016-2020). Intraclass relationship testing was utilized for dependability appraisals; Mann-Whitney U tests and Sign tests were utilized individually for intercohort and intracohort similar investigations. ALIFs created more prominent segmental and L4-S1 lordosis than TLIF, both at first postoperative visit (mean 26 days [SE=4]; 11.3° vs. 1.3°, P<0.001; 6.2° vs. 0.3°, P=0.005) and at last development (mean 410 days [SE=45]; 9.6° vs. 0.2°, P<0.001; 7.9° vs. 2.1°, P=0.005). ALIF additionally exhibited more major expansion in circle level than TLIF from the beginning (9.6 vs. 5.5 mm, P<0.001) and last development (8.7 vs. 3.6 mm, P<0.001). In the ALIF bunch, the circle level was kept up with but diminished after some time in the TLIF associate (ALIF 9.6 vs. 8.7 mm, P=0.1; TLIF 5.5 vs. 3.6 mm, P<0.001). The 2 gatherings exhibited upgrades in Pain Intensity and Pain Interference scores; ALIF patients likewise worked on Physical Function and Global Health – Physical spaces. ALIF produces more prominent segmental lordosis, territorial lordosis, and reclamation of plate level contrasted with TLIF for treatment of isthmic spondylolisthesis. Furthermore, ALIF patients show critical enhancements across additional PROMs spaces compared with TLIF patients.