This study is aimed to assess the outcomes of radiotherapy. IMN is defined as a regional node similar to the ALN, previous studies have suggested that breast cancer involving IMN has a worse prognosis than that involving ALN metastasis. Although there are controversies regarding the negative prognostic influence of IMN+, there is an increasing need to optimize management for IMN + breast cancer. The neoadjuvant chemotherapy (NAC) is increasingly used to treat locoregionally advanced breast cancer [15], radiotherapy is needed to be adjusted according to the response to NAC. The radiation dose to the IMN was converted to an equivalent dose in 2 Gy fractions (EQD2) using the linear quadratic model with α/β of 3.5 Gy. Disease-free survival (DFS), IMN failure-free survival (IMNFFS), LRR-free survival (LRRFS), and DM-free survival (DMFS) were defined as the interval from the date of NAC to the date of cancer recurrence. Variables with a significance at p < 0.05 on univariate analysis were included in the multivariable analysis.

The results were observed which showed that the median size of the IMN was 0.8 cm (range, 0.2–2.0 cm) at initial breast cancer diagnosis.Positron emission tomography-computed tomography was performed in 166 patients (96.4%) at time of breast cancer diagnosis.

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