Thrombotic events in adult patients with inflammatory bowel disease (IBD) are associated with numerous combinations of genetic and acquired risk factors. There was a scarcity of published data on children with IBD. For a study, researchers sought to determine the thromboembolic risk factors in children with IBD. They recruited three groups of children: one with Crohn’s disease (cD), another with ulcerative colitis (Uc), and a healthy control group. The possible thromboembolic risk was examined clinically and by laboratory testing for all individuals.
They evaluated 30 CD children (25.6%), 28 UC children (23.9%), and 59 (50.4%) healthy control participants. There were no significant differences between thromboembolic risk variables and disease activity as measured by the Pediatric Crohn Disease Activity Index. Instead, there was a statistically significant difference in serum fibrinogen levels between kids with mild and moderate/severe UC, as measured by the Pediatric Ulcerative Colitis Activity Index [3.8 (3.2–4.5) g/L vs. 5.7 (4.8–6.2) g/L, P<0.0032]. Healthy controls had lower blood homocysteine levels than CD (P=0.176) and UC (P=0.026) patients. A homozygous mutation in the methylene tetrahydrofolate reductase C677T gene resulted in a rise in homocysteine levels in UC. The research found that, like adults, children with IBD had clinical characteristics and acquired and congenital variables that might raise the thrombotic risk.