To conduct a literature review on risk factors for chronic rhinosinusitis (CRS), with a focus on genetic, concomitant illness, and environmental variables linked to CRS. Researchers wanted to get insights into the underlying pathogenic mechanisms necessary for establishing successful treatment methods by identifying possible risk factors for CRS. Recent research shows that having a CRS diagnosis is linked to genetics and comorbid medical disorders like respiratory illnesses, gastric reflux disease, inflammatory and autoimmune diseases, as well as different demographic and environmental variables. Current studies include limitations such as varying illness criteria, a lack of prospective longitudinal research, and a disproportionate focus on tertiary care populations.

CRS is associated with a wide range of variables, including genetics, concomitant illnesses, and environmental factors. These risk variables may give useful information for the development of therapeutic and preventative treatments. However, more research is needed to determine if these correlations cause CRS, establish temporal linkages between exposure and illness start, assess the influence of exposure dosage on disease severity, and comprehend the biological consequences of these risk factors in the setting of CRS.