Individuals with HIV experienced nearly the same risk for a positive SARS-CoV-2 test as the general population, according to a study published in AIDS. Investigators aimed to determine the risk for a positive SARS-CoV-2 test, COVID-19 outcomes, and the association with vaccination status among adults with HIV (N=5,276) versus an age and sex-matched cohort (N=42,308). They reported no major difference in risk for first positive SARS-CoV-2 test (adjusted incidence rate ratios [aIRR]: 0.8; 95% CI, 0.8-0.9), but an increased risk for first hospital contact with COVID-19 and hospitalization with severe COVID-19 for people with HIV versus controls [IRR: 2.0 (95% CI, 1.6–2.5) vs 1.8 (95% CI, 1.4-2.3)]. Risk for first hospitalization was significantly reduced among people with HIV in the first half of 2022 versus 2020 (IRR: 0.3; 95% CI, 0.2-0.6); the risk compared with the general population remained
higher by nearly two-fold. Compared with people with HIV who had two COVID-19 vaccines, people with HIV who received a third dose experienced a lower risk for a first positive SARS-CoV-2 test (aIRR: 0.9; 95% CI, 0.7- 1.0), death among individuals aged 60 and older (aIRR: 0.2; 95% CI, 0.1-0.7), and hospitalization (aIRR: 0.6; 95% CI, 0.2-1.2).