Although the potential benefit of additional screening examinations in moderate risk patients (patients with a history of breast cancer in one or two family members) remains unclear. Breast cancer patients with a first degree family history of breast cancer had a higher number of performed mammograms. Large case-control study with data about family history of breast cancer of 3813 cases and 7341controls and follow-up data. The researchers assessed whether more frequent screening due to a positive family history was associated with overall and breast cancer specific survival after accounting for clinical and tumor characteristics. Two population-based controls without a history of breast cancer matched by age and study region were recruited for each case. Study participants were prospectively followed until June 30, 2015. The primary endpoints were overall survival (OS: including death from any cause), breast cancer-specific survival (BCS (non-breast cancer-related deaths were censored), and recurrences (including ipsilateral, contralateral, local/regional invasive recurrence, and distant recurrence). Having a small tumor (below 2 cm versus above) or being node-negative (pN0 versus other) was the dependent variable. 

The results obtained were a high rate of childbirth in both groups (88.5% vs. 85.9%). There was a higher proportion of cases than controls who never breastfed (never breastfed: cases: 37.6% vs. controls 33.4%, p < 0.001). There were no differences in breast cancer subtypes between cases with and cases without positive family history of breast cancer (p = 0.073).

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