It is believed that between 250 and 500 cases/100.000 individuals per year are attributable to sepsis, making up between 4 and 6% of all hospital admissions. Sepsis has been named 1 of the world’s most pressing health issues and is also the leading cause of healthcare expenditures. There is little data on how the management of sepsis-associated organ failure has changed and whether or not it has contributed to a decrease in mortality, even though there have been significant advances in the care of septic patients in recent years. Hospital discharge records from the Minimum Basic Data Set Acute-Care Hospitals (CMBD-HA in Catalan language) for the Catalan Health System (CatSalut). All Catalan acute care hospitals, both public and private, are required to report patient admissions to the CMBD-HA registry. The combination of an infection and the failure of at least one organ was traditionally used to diagnose sepsis. The presence of sepsis in hospitalized patients was identified using the ICD-9-CM (from 2005 to 2017) and ICD-10-CM (2018 and 2019) codes used to identify acute organ dysfunction and infectious processes. During the study period (2005-2019), sepsis affected 296,554 out of 11,916,974 hospital discharges. From 2005 to 2019, the average yearly incidence of sepsis in the population rose from 144.5 to 410.1 per 100,000 people. About 21% of patients had a multi-organ failure, and 26% had bacteremia. The most common organ failure was renal (56.8%), followed by cardiovascular (24.2%). Hospital mortality was 19.5% during the study period. However, it steadily declined from 25.7% in 2005 to 17.9% in 2019 (P<0.0001). Cardiovascular failure deaths have dropped the most dramatically, from 47.3% in 2005 to 31.2% in 2019 (P<0.0001). Similarly, there has been a significant decline in the median fatality rate due to renal and respiratory failure in sepsis in recent years (P<0.0001). In recent years, sepsis in the United States has risen. However, death rates in hospitals have dropped dramatically. With the exception of liver failure, all other types of organ failure in septic patients have shown a statistically significant reduction in related mortality.