The hazard for the occurrence of cardiovascular disease (CVD) occasions among moderately aged or more seasoned grown-ups is known to be correlated with serum urate levels. In any case, the trajectory of serum urate during youthful adulthood and its relationship with cardiovascular disease occasions has not been studied sufficiently. We concluded that sex-specific serum urate trajectories utilizing SAS PROC TRAJ after exploiting serum urate estimations gathered at benchmark and 10, 15, 20 years after standard from 3563 CARDIA (Coronary Artery Risk Development in Young Adults) members (average age (in years)=25.1±3.6; % of Black=46.3; % ladies=56.1). We assessed peril proportions for CVD occasions (heart failure, coronary heart disease, and stroke) happening after the year 20 test through 2017. We gave recognition to three gender-specific serum urate directions. The three trajectories included low-steady (total observations=1251), moderate-stable (total observations =1761), and high-rising (total observations =551). 157 incident cardiovascular disease occasions took place following the follow-up [median years = 10.6]. Members among the high-rising trajectory bunch had 2.89 (95% CI, 1.88–4.43) times more danger for CVD in comparison to the low-steady trajectory bunch. The affiliation was constricted after change for BP levels during youthful adulthood. Taking everything into account, the high-rising serum urate trajectory during youthful adulthood was related to the occurrence of CVD by middle age, and the affiliation might be clarified by BP levels during the openness time frame.