The purpose of the study was to analyze if the sFlt-1/PlGF ratio is more useful than other parameters at diagnosis of early-onset PE in the prediction of delivery within 48 h and adverse maternal and perinatal outcomes.

An observational retrospective study method was used to collect the data for this study. The research method was applied to a cohort of 76 singleton pregnancies with early-onset PE and expectant management. The predictive value of the sFlt-1/PlGF ratio, blood pressure, proteinuria, creatinine, liver enzymes, and platelets at diagnosis for delivery < 48 h and adverse outcomes were determined.

Maternal and perinatal adverse outcomes occurred in 25/76 cases and 13/69 livebirths, respectively. AUC for sFlt-1/PlGF ratio was 0.59 and 0.75 for maternal and perinatal complications, respectively. Mean time to delivery for a sFlt-1/PlGF ratio > 655 vs. ≤ 655 was of 4.4 (7.5) vs. 12.1 (9.3) days, p < 0.01. Relative risk for delivery within 48 h for a sFlt-1/PlGF ratio > 655 was 5.3, p < 0.01.

The findings of this study concluded that the sFlt-1/PlGF ratio > 655 at diagnosis was associated with a 5-fold increased risk of delivery in ≤ 48 h. None of the parameters were good predictors of adverse maternal or perinatal outcomes.

Reference: https://www.sciencedirect.com/science/article/abs/pii/S2210778920300945