Although coagulase-negative staphylococcus germs were common in human skin, they could also be pathogens in the skin and soft tissue infections. For a review, researchers provided an overview of coagulase-negative staphylococcus species infections of the skin and soft tissues. They searched PubMed for abscess, auricular, biofilm, capitis, cellulitis, coagulase, contaminant, cyst, draining, epidermidis, felon, folliculitis, furuncle, haemolyticus, hominins, indolent, infection, lugdunensis, mecA, microbiome, negative, osteomyelitis, paronychia, saprophyticus, skin. The search yielded pertinent publications and their references, which were examined. Many coagulase-negative staphylococcus organisms have been found to cause skin and soft tissue infections, including Staphylococcus auricularis, Staphylococcus capitis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus lugdunensis, Staphylococcus saprophyticus, and Staphylococcal Abscesses and paronychia are the most common symptoms of coagulase-negative staphylococcus skin infections. They were particularly frequent in older people or those who are immunocompromised and were often treatable with antibiotics. 

Finally, coagulase-negative staphylococcus species, albeit less prevalent, caused skin and soft tissue infections, especially in the elderly and/or immunocompromised. A survey of the literature revealed that coagulase-negative staphylococcus species were more typically developed in abscess and paronychia cultures. As a result, coagulase-negative staphylococcal organisms should not be regarded as pollutants or natural flora, but rather as pathogenic pathogens. Antibiotics used to treat methicillin-sensitive Staphylococcus aureus were typically effective against them.