Researchers conducted a research project that included a systematic review. For a study, they sought to look over the current literature to see the rates of complications in ambulatory surgical centers (ASC) when it comes to spine surgery. Complication rates were not consistently reported despite the benefits and decreased costs associated with ASCs. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used to accomplish this systematic review. The search string ((“ambulatory surgery centre”) AND “spine surgery”) AND “complications”) was used to find relevant studies in the Embase and PubMed databases. Articles that did not record outpatient surgery in an ASC did not define complications, were written in a language other than English, were non-human research, or were classed as reviews, book chapters, single case reports, or short case series (≤ 10 patients) were all removed. The frequency of problems in various categories was the immediate result. As a result of the inquiry, investigators were able to find 150 articles. About 22 articles were chosen after being filtered for relevancy by title, abstract, and full text. In the investigation, 11,245 patients were evaluated after accounting for 2 studies conducted on the same study population. Results from the most current study were released in May of this year. While 5 studies did not specify their surgical approach, others mentioned open surgery, minimally invasive surgery, endoscopic surgery, microsurgery, and a combination of procedures. Complication rates were calculated as follows: cardiac 0.29% (3/1027), vascular 0.25% (18/7116), pulmonary 0.60% (11/1839), gastrointestinal 1.12% (2/179), musculoskeletal/spine/operative 0.59% (24/4053), urologic 0.80% (2/250), transient neurological 0.67% (31/4616), persistent neurological 0.61% (9/1479), pain-related 0.57% (20/3479), wound site 0.68% (28/4092). Based on a literature review, this was the first study to examine the present level of knowledge on the complication profile of all ASC spine surgery procedures. The most prevalent problems (1.12%) were gastrointestinal, whereas the least common were vascular (0.25%). The nature and frequency of problems reported in case reports varied greatly. The research gives complication profiles to help surgeons guide patients on what they should expect.