The door has been opened for the initiation of randomized controlled clinical trials for establishing the efficacy of fluorescent light energy (FLE) treatment in different phases of wound healing of second-degree burns, according to a study published in Military Medicine. With recent developments in photobiomodulation leading to the development of a novel biophotonic platform that uses FLE within the visible spectrum of light for healing of skin inflammation and wounds, researchers assessed the use of FLE in a preliminary analysis of 19 case study of acute second-degree burns and in a pilot study using an ex vivo human skin model. The efficacy of FLE in achieving wound healing and tissue remodeling was evaluated by monitoring improvements in treated tissues, assessing patient’s pain, and conducting human genome microarray analysis of treated human skin samples. All 18 patients treated with FLE reported healing without adverse effects or infections. The ex vivo skin model data suggested that FLE impacts various cellular pathways, including essential immune-modulatory mechanisms.