Adults are increasingly being diagnosed with primary immunodeficiency disorders. Although infections are the most prevalent cause of symptoms, patients may also present with complications from autoimmune and noninfectious pulmonary illnesses such as interstitial lung disease and granulomatous disease. Patients with varied and, at times, subtle symptoms suggestive of immunodeficiency are likely to be seen by pulmonologists. 

The study covers the presentation, assessment, and management of four antibody deficits in this review article: common variable immunodeficiency, selective immunoglobulin A deficiency, specific antibody deficiency, and immunoglobulin G subclass deficiency.