The purpose of this paper is to conduct a systematic review and meta-analysis of available data on the comparison of health-related quality of life (HRQOL) in children and adolescents with celiac disease (CD) to healthy children. Furthermore, a meta-analysis was carried out to compare the parent proxy report with the kid self-report of HRQOL. From inception to April 2019, the databases of PubMed, Embase, Scopus, and the Cochrane library were searched to locate observational studies that examined HRQOL in children with CD. There were studies that compared the HRQOL of celiac patients and healthy children, as well as the parent’s proxy report and the child’s self-report of HRQOL. 26 articles fulfilled the set inclusion criteria after researchers conducted a thorough search. The meta-analysis of studies utilizing the PedsQL questionnaire found that the total HRQOL score did not differ substantially between celiac patients and healthy controls. According to the findings of meta-analysis, parents reported lower diet and communication ratings for their children than children reported for themselves. Only four of the eleven research found a significant relationship between HRQOL and gluten-free diet (GFD) adherence, and two of the four studies found a significant negative relationship between HRQOL and age at diagnosis.

The current study’s findings revealed that there was no significant difference in HRQOL between children with CD and healthy controls. Furthermore, parents’ perceptions of their children’s HRQOL were lower than children’s perceptions.