#VisualAbstract: Addition of radiotherapy to anti-PD-1 therapy does not improve survival in advanced mucosal melanoma
Click to read this study in the European Journal of Cancer.
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2MM
Australian RSV epidemic seasonality – but not severity – altered by COVID-19
1. RSV infections and hospitalizations peaked in December of 2020, a significant change in timing from the usual autumn and winter epidemics of the last six years, according to epidemiologic research from the Sydney Children’s Hospital Network. 2. There were significant differences in age distribution of RSV disease burden, but not disease severity, as measured by […]
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Tricuspid repair in patients with mitral regurgitation offers clinical benefits
1. In patients with severe degenerative mitral regurgitation who received mitral-valve surgery, those who also received tricuspid regurgitation surgery had less frequent progression to severe tricuspid regurgitation. 2. Incidence of pacemaker implantation was higher in patients who received concomitant tricuspid repair along with mitral-valve surgery. Evidence Rating Level: 1 (Excellent) Study Rundown: Tricuspid regurgitation is […]
Read MoreLenvatinib plus pembrolizumab increased survival for advanced endometrial cancer patients when compared to chemotherapy
1. The median progression-free survival and overall survival was longer with lenvatinib plus pembrolizumab than with chemotherapy. 2. Clinically important adverse events in the combination group included hypertension, thyroid dysfunction, colitis and diarrhea Evidence Rating Level: 1 (Excellent) Study Rundown: Advanced endometrial cancer after platinum treatment remains difficult to treat and fiver-year survival remains poor. […]
Read MoreBRCA1/2 pathogenic variants are associated with an increased risk of male breast, pancreatic, and stomach cancer.
1. Pathogenic variants of BRCA1 or BRCA2 are associated with an increased risk of pancreatic and stomach cancer in both sexes 2. Only BRCA2 carriers have an increased risk of prostate cancer Evidence Rating Level: 2 (Good) Study Rundown: Pathogenic variants (PVs) of BRCA1 and BRCA2 are known to be associated with an increased risk […]
Read MoreExtreme prematurity associated with increased prevalence of visual and ocular deficits in young adults
1. Extreme prematurity was associated with an increased prevalence of visual and ocular deficits, suggesting children born extremely preterm may have residual ophthalmic sequelae persisting into adulthood. 2. These findings emphasized the need for screening and management of any deficits as they evolve long-term at a population-level. Evidence Rating Level: 2 (Good) Study Rundown: Although […]
Read MoreHybrid closed-loop therapy improves glycemic control for children with Type 1 Diabetes
1. In very young children with type 1 diabetes, a hybrid closed-loop therapy provided significantly improved glycemic children. 2. The hybrid closed-loop therapy did not significantly increase the time spent in hypoglycemia in very young children with type 1 diabetes. Evidence Rating Level: 1 (Excellent) Study Rundown: In very young children, managing Type 1 Diabetes […]
Read MoreIntracranial efficacy of alectinib in ALK-positive NSCLC patients with CNS metastases
1. Treatment with alectinib reduced CNS lesion sizes and significantly improved symptoms, ECOG performance scores and requirements for mannitol and corticosteroids in patients with metastases from non-small cell lung cancer. Evidence Level Rating: 2 (Good) Central nervous system metastases are highly prevalent in patients with ALK gene mutations driving advanced non-small cell lung cancer despite […]
Read MoreUse of different sepsis scoring systems to predict mortality in bacteremic patients
1. Shapiro criteria and qSOFA scores significantly predicted sepsis-related mortality in bacteremic patients. 2. Model performance measures did not strongly support the independent use of sepsis criteria to screen for bacteremia in emergency departments. Evidence Level Rating: 2 (Good) While bacteremia associated with sepsis is associated with high mortality rates, prompt identification of sepsis and […]
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Convalescent plasma is not effective at improving clinical outcomes or reducing mortality of COVID-19 patients not on mechanical ventilation
1. This meta-analysis found that treatment with COVID-19 convalescent plasma (CCP), compared to control group treatment, did not improve clinical outcomes, as measured by the World Health Organization clinical outcome score, or mortality. 2. There was an improvement in the mortality and clinical outcomes for participants treated with CCP who had a baseline WHO score […]
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Bystander intervention may improve survival after exercise-related sudden cardiac arrest
1. On average, 71% of exercise-related sudden cardiac arrest (SCA) received bystander cardiopulmonary resuscitation (CPR) and 31% had an automated external defibrillator (AED) applied by a bystander. 2. The median survival rate to hospital discharge among exercise related SCA was 32% Evidence Rating Level: 1 (Excellent) Sudden cardiac arrest (SCA) is an issue affecting competitive […]
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