ASCO 2021 Ovarian Cancer
The EFFORT needed to overcome PARP resistance in ovarian cancer
Jul 8, 2021
Adavosertib with or without olaparib demonstrated clinical activity with a manageable toxicity...
Read MoreRacial Disparity Examined in BRCA1/2 Testing in Ovarian Cancer
Jul 1, 2021
Genetic testing for BRCA1/2 mutations is recommended for all women with ovarian cancer, given the important implications for treatment and prognosis, according to the Caitlin E. Taylor, MD, lead author of a paper presented at...
Read MoreRacial Disparities in Ovarian Cancer Treatment and Overall Survival
Jul 1, 2021
It has long been identified that Black women with ovarian cancer have worse overall survival when compared to White women, explains Deanna L Huffman, DO, Department of Internal Medicine, Allegheny Health Network, in Pittsburgh....
Read MorePatient-Centered Communication Can Aid QOL in Women With Ovarian Cancer
Jul 1, 2021
Effective patient-clinician communication (PCC) is central to the delivery of high-quality care, according to the National Cancer Institute (NCI), and it becomes even more crucial in the cancer setting where patients deal with...
Read MoreExamining Treatment Symptom Burden & Management in Ovarian Cancer
Jul 1, 2021
A better understanding of the burden of treatment side effects in patients with gynecological malignancies could help guide symptom interventions and oncologic therapy decision-making, according to Ashley D. Hickman, MD, the...
Read MoreEFFORT: EFFicacy Of Adavosertib Plus Olaparib, PARP-resistant Ovarian Cancer
Jul 1, 2021
Adavosertib with or without olaparib shows efficacy in women with PARP inhibitor-resistant ovarian cancer (Abstract #5505) Clinical trial results from the randomized, non-comparative Phase II EFFORT study showed that...
Read MoreJAVELIN Ovarian 200: Avelumab Shows No Survival Benefit
Jun 24, 2021
Given either alone or in combination with chemotherapy PFS, OS not improved, study suggests...
Read MoreOlaparib/Bevacizumab Provides Substantial PFS in Advanced Ovarian Cancer
Jun 23, 2021
The phase III PAOLA-1/ENGOT-ov25 trial evaluated the addition of maintenance olaparib to bevacizumab in women with advanced ovarian cancer who were in response after first-line platinum-based CTx with bevacizumab. In the Phase...
Read MoreAdavosertib-Olaparib Combo Improves Efficacy Treating PARP inhibitor-resistant Ovarian Cancer
Jun 23, 2021
Clinical trial results from the randomized, non-comparative Phase II EFFORT study showed that adavosertib, a Wee1 inhibitor, was effective in patients with PARP inhibitor-resistant ovarian cancer when given alone and in...
Read MorePrimary Debulking Surgery Bests Neoadjuvant Chemo in High-Grade Serous Ovarian Cancer
Jun 16, 2021
Earlier detection of primary ovarian tumor could extend survival in some patients When complete...
Read MoreNovel drug combination for recurrent ovarian cancer
Jun 15, 2021
Mirvetuximab soravtansine, a folate receptor-targeting antibody-drug conjugate, in combination with bevacizumab, demonstrated impressive anti-cancer activity in the phase 1b FORWARD II trial. Mirvetuximab soravtansine (MIRV) is...
Read MoreAdjuvant chemotherapy does not improve outcome in patients with locally advanced cervical cancer
Jun 15, 2021
Results of the randomized, phase 3 OUTBACK trial do not support the use of adjuvant chemotherapy after chemoradiation in women with locally advanced cervical cancer. At 5 years, both overall and progression-free survival were...
Read MoreASCO 2021: Olaparib Upholds PARP Inhibitor Use in Ovarian Cancer
Jun 4, 2021
Progression-free survival (PFS) and second PFS (PFS2) by disease stage in patients (pts) with homologous recombination deficiency (HRD)-positive newly diagnosed advanced ovarian cancer receiving bevacizumab (bev) with...
Read MoreASCO 2021: Few Patients with Ovarian Cancer Undergo Genetic Testing
Jun 4, 2021
Testing for mutations in BRCA1 and BRCA2 is recommended for all women with ovarian cancer, given important implications for treatment and prognosis. Despite this recommendation, studies show that only a small percentage of...
Read MoreASCO 2021: Ten Minute Questionnaire Identifies Lynch Syndrome
Jun 4, 2021
Although ovarian cancer is the third most common Lynch syndrome (LS)-associated cancer in women, there is no established screening strategy to identify LS in this population. It is hypothesized that an adequate family history...
Read MoreASCO 2021: Ovarian Cancer Outcomes Impacted by Adherence to NCCN Guidelines
Jun 4, 2021
Disparities in the adherence to National Comprehensive Cancer Network (NCCN) guideline-directed treatment and socioeconomic characteristics may be responsible for the differences in ovarian cancer outcomes of ovarian cancer in...
Read MoreASCO 2021: Patient-Centered Communication Improves HRQoL
Jun 4, 2021
The National Cancer Institute (NCI) Framework for patient-centered communication (PCC) in Cancer Care highlights the potential of PCC to improve health-related quality of life (HRQoL), but to date, few studies have empirically...
Read MoreThe Insider’s Guide to ASCO 2021: Ovarian Cancer
Jun 3, 2021
The ASCO Annual Meeting enters its second year in a virtual setting June 4-8, 2021, to ensure the safety and health of attendees while delivering groundbreaking science in oncology and timely information on clinical application...
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