A Focus on Uterine Cancer eBook
Focus on Uterine Cancer
CID2189
Unmet Needs for Gynecologic Malignancy
There remains an “urgent need” for better therapies, as well as earlier diagnosis and earlier identification of recurrences, in endometrial cancer, according to the authors of a study published in The Oncologist. The...
In Vivo And In Vitro Mapping Of The Temporal And Spatial Dynamics Of The Human Endometrium
The endometrium, the uterine mucosa, changes dynamically in response to ovarian hormones throughout the menstrual cycle. Researchers created rich single-cell and spatial reference maps of the human uterus, as well as...
Uterine Cancer Risk is Associated With Testosterone, Sex Hormone-Binding Globulin, Insulin-Like Growth Factor-1, And Sex Hormone-Binding Globulin
Endometrial cancer risk may be modified by dysregulation of endocrine pathways associated with steroid and growth hormones; however, prospective data on testosterone, sex hormone-binding globulin (SHBG), and insulin-like growth...
Methylation Of The m6A mRNA Affects AKT Activity, Promoting Uterine Cancer Proliferation And Tumorigenicity
Methylation of N6-methyladenosine (m6A) messenger RNA is a gene regulation mechanism that affects cell differentiation and proliferation in development and cancer. Researchers analyzed human endometrial cancer with a hotspot...
Research Reveals Potential Genes And Tissue-Specific Gene Expression That Contributes To Uterine Cancer Risk
Although genome-wide association studies (GWAS) have identified sixteen risk loci for endometrial cancer, identifying prospective susceptibility genes remains difficult. Researchers used the largest endometrial cancer GWAS and...
Cytology’s Diagnostic Accuracy In Detecting Uterine Cancer In Urine And Vaginal Samples
For the 90–95% of women who do not have endometrial cancer, postmenopausal bleeding necessitates a prompt examination with invasive tests that are not necessary. A simple, non-invasive instrument that correctly detects cancer...
A Radiogenomics Application For Uterine Cancer Prognostic Profiling
Endometrial cancer prognosis is crucial for correct diagnosis and customized treatment (EC). Researchers employed radiogenomics to integrate preoperative magnetic resonance imaging (MRI, n = 487 patients) with histologic-,...
SPTBN2 Promotes Uterine Cancer Growth Via The CLDN4/PI3K/AKT Axis, Which is Controlled By miR-424-5p
The most common kind of endometrial cancer is endometrioid endometrial cancer (EEC). SPTBN2 was shown to be highly overexpressed in EEC tissues, according to the findings. SPTBN2 overexpression was linked to a poor prognosis. ...
MRI & Radiomics for Cancer Recurrence Risk Assessment
With the increasing prevalence among Americans of risk factors like physical inactivity and overweight, the incidence of endometrial cancer (EC) continues to rise, according to a study published in BMC Cancer. Although most ECs...
Weight Loss, the Immune Microenvironment & Uterine Malignancy Prevention
Although prior research has shown that obesity increases the risk for endometrial cancer and that weight loss is protective, the underlying mechanisms are incompletely understood, according to the authors of a study published in...
Multispectral label-free Raman spectroscopy can detect gynecologic cancer with high accuracy.
Up to 70% of ovarian cancer patients are diagnosed with advanced-stage disease and the degree of cytoreduction is an important survival prognostic factor. The aim of this study was to evaluate if Raman spectroscopy could detect...
