Cardiovascular function reserve is the difference between the normal rate at which the heart pumps blood and its maximum rate of pumping blood at a given time. In some medical conditions, the measurement of the cardiovascular reserve may be a health indicator. Kidney transplant can improve the rate of survival in patients with chronic kidney disease, but its effect on the cardiovascular system is not well studied. This study aims to evaluate the effect of a kidney transplant on cardiovascular function reserve.

This is a randomized, prospective, controlled, single-center, 3-arm, cohort study that included a total of 253 participants with stage-5 chronic kidney disease (CKD) who underwent a kidney transplant (KTR group, n=81)or did not undergo a kidney transplant (NTWC group, n=85); or those with hypertension only (HTC group, n=87). Patients were followed-up for 1 year after a kidney transplant, and the primary outcome was the cardiovascular function reserve.

The findings suggested that mean (SD) maximum oxygen consumption was substantially lower in the CKD groups (KTR: 20.7 mL/min, NTWC: 18.0 mL/min), compared with the HTC group (24.9 mL/min). Overall, a kidney transplant was associated with an improvement in oxygen consumption at 12 months than the NTWC group.

The research concluded that kidney transplant was associated with a significant improvement in cardiovascular function reserve after 1 year.