Both Crohn’s (CD) and corticosteroids inflammatory load adversely impact bone density. Endoscopic healing is prevented and promoted with the exclusionary enteral nutrition (EEN). The researchers looked at nutritional therapy in paediatric CD for the influence of bone health. This was a proposed sub-study of a new, mild-moderate CD trial involving children. The children were either assigned to 6 weeks of EEN, followed by 6 weeks by a 25% enteral diet (PEN) or a 50% PEN diet for 6 weeks, followed by a 25% PEN diet with exclusion. Collagen N-Telopeptide serum (NTX) was evaluated for the development of bones and their resorption at baseline, Week 12 and Week 24. Dual energy X-ray absorption (DXA) scan was assessed in baseline and week 24 by Bone Mineral Density (BMD).

At Week 24, median CICP improved from 130 ng/mL in baseline to 223 in week 12 and 193. Median NTex remained unchanged. DXA scans were performed for 38 youngsters, with z rates of <−1 and <−2, respectively of 81 and 33 percent. Scores of DXA z did not improve at weeks 24 from baseline. In new, mild-moderate paediatric CD, low bone density is prevalent. After dietary operation, CICP, a sensitive bone formation marker, was enhanced but not linked to improved BMD.

Reference: https://journals.lww.com/jpgn/Abstract/2021/06000/The_Effect_of_Nutritional_Therapy_on_Bone_Mineral.18.aspx